Jeff Ramage sent me a suggestion that I like a lot.

Green Bank, WV.
Check in at
Snowshoe Mountain
http://www.snowshoemtn.com

Early evening
The Green Bank Telescope
http://www.gb.nrao.edu/
http://en.wikipedia.org/wiki/Nationa..._West_Virginia

Sunday morning
Cass Scenic Railway
http://www.cassrailroad.com/

I haven't looked at a map yet, but it looks interesting.